Fig. 2
From: CART cells are prone to Fas- and DR5-mediated cell death
The programmed cell death of CD8 CART cells occurs independently of TCR engagement. a Scheme of the experiment involving either BFP or HER2-BBz CAR transduced OT-1 T cells in mice that were conditioned with cyclophosphamide. b Frequencies of BFP or HER2-CART cells out of total live cells in the spleen at day 14 post transfer. c Fas, FasL, DR5, TRAIL and Annexin V expression in BFP or HER2-CAR OT-1 T cells at day 14 post transfer. Statistical analysis by T-test, n = 4 mice per group. * P < 0.05, ** P < 0.01, *** P < 0.001 and **** P < 0.0001