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Fig. 2 | Journal for ImmunoTherapy of Cancer

Fig. 2

From: Fatal enteric plexus neuropathy after one dose of ipilimumab plus nivolumab: a case report

Fig. 2

Representative histology from a control section of comparably autolyzed colon (not from this patient) demonstrating a representative myenteric ganglion (a) containing ganglion cells (arrowheads) and scattered surrounding glia. This is in contrast to the patient’s ganglia (b) which show morphologic absence of ganglion cell bodies and no conspicuous inflammatory infiltrate. While myenteric ganglions cells in control tissue (not from this patient) are highlighted by anti-Hu (c, arrowheads), no immunoreactive ganglion cells are present in this patient (d). Rare submucosal ganglion cells were seen (Fig. 2b and d, insets). Similarly, immunohistochemistry using PGP9.5 on the control myenteric plexus (e) highlights neuronal bodies (arrowheads), adjacent neural processes (np) and intramuscular nerves (in), in contrast to the patient whose myenteric plexus (f) demonstrates sparse residual processes in the plexus and no intramuscular nerves. Immunohistochemistry for SOX10 in both the control plexus (g) and the patient’s tissue (h) show residual glial cells (arrowheads). Scale bars: 50 μm

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