Fig. 3

C4d immunoreactivity around ganglia and nerves. a Intense C4d immunolabelling is observed around an aneuronal ganglion (g) and in the location of small intramuscular nerves (arrows) in the colon of the patient. b In contrast, no significant C4d expression is observed in ganglia (g) in the colon from a cadaveric control patient with no history of ipilimumab or novilumab exposure or dysmotility. v, blood vessel. Scale bars = 100 μm