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Fig. 2 | Journal for ImmunoTherapy of Cancer

Fig. 2

From: Treatment of mycophenolate-resistant immune-related organizing pneumonia with infliximab

Fig. 2

Histology of metastasis and organizing pneumonia. a, b Wedge resection of the lung after immunotherapy. The melanoma metastasis shows excellent response to treatment with extensive regressive necrosis. (HE, original magnification 25× and 200×, respectively). Here only melanin pigment and necrosis with lack of vital tumor cells are present. c, d Distant to the necrotic metastasis circumscribed areas of immunotherapy-induced organizing pneumonia with intraalveolar fibromyxoid proliferations and mild lymphoplasmacytic inflammation (HE original magnification 12,5× and 200×, respectively). (e) Immunhistochemical analysis of CD3+ cells in inflammatory lesions (200× magnification). f, g Staining of CD4+ (f) and CD8+ (g) cells (200× magnification). h Staining for FOXP3+ regulatory T cells in inflammatory lesions (200× magnification). i Immunostaining for PD-L1 in inflammatory lesions (100× magnification, SP-263 clone)

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