Table 1 Cytokines influenced (alteration>2folds) by AGT silence
From: Local angiotensin II contributes to tumor resistance to checkpoint immunotherapy
Cytokines | Functions |
|---|---|
Immune-activating | |
 IL-7 | Necessary for both B-cell and T-cell proliferation [43]. |
 IL-20 | Enhancing innate and adaptive immunity [44]. |
 CD40 ligand | A potent dendritic cell activation molecule, counteracting immune escape mechanisms in the tumor microenvironment [45, 46]. |
 CXCL1 | Pro-inflammatory cytokine: the activation and regulation of innate and adaptive immunity [53]. |
 CXCL11 | Chemotactic for activated T cells [47]. |
 CXCL14 | Attraction of dendritic cells [48] |
 TNFSF14 | Stimulating lymphocyte proliferation and tumor cell-specific anti-tumor immune responses [49]. |
Immunosuppressive | |
 IL-3 | Promoting dendritic cells secreting significantly less IL-12 p70 and more IL-10 [54] |
 IL-4 | Participating in both TAM and MDSC survival and the acquisition of an immune-suppressive phenotype [55, 56]. |
 IL-10 | Inhibiting the ability of APCs to present antigens to T cells [57] |
 Fas | Inducing apoptosis of cytotoxic T lymphocytes through the FAS-FASL pathway [58] |
 Fas ligand (FASL) | Inducing apoptosis of cytotoxic T lymphocytes through the FAS-FASL pathway [58] |
 CCL1 | Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege [59] |
 CCL7 | Chemoattracting MDSCs and Tregs in tumor microenvironment [60]. |
 SDF-1 | Increasing immunological tolerance by polarizing Tregs [61]. |
 CCL28 | Recruiting Tregs in tumor hypoxia microenvironment [62]. |
 G-CSF | Recruiting MDSCs in tumor hypoxia microenvironment [63]. |
 GM-CSF | Shaping the tumour microenvironment by promoting myelopoiesis and recruitment of suppressive myeloid cells [55, 64, 65] |
 Eotaxin-2 | |
 TNFSF12 | Curtailing the innate response and its transition to adaptive TH1 Immunity [68]. |