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Table 2 Association between TILs and other immunological biomarkers in the primary cohort (n = 95)

From: A nomogram-based immunoprofile predicts overall survival for previously untreated patients with esophageal squamous cell carcinoma after esophagectomy

Biomarker CD8 rich (n = 56) CD8 poor (n = 39) P value CD4 rich (n = 76) CD4 poor (n = 19) P value
No. of patients No. of patients   No. of patients No. of patients  
Foxp3    0.002    0.010
  ≥ 1% 37 13   45 5  
  < 1% 19 26   31 14  
CD33    0.682    0.119
  ≥ 1% 38 28   50 16  
  < 1% 18 11   26 3  
PD-1    0.919    0.470
  ≥ 1% 25 17   35 7  
  < 1% 31 22   41 12  
PD-L1-TC    0.555    0.581
  ≥ 1% 19 11   23 7  
  < 1% 37 28   53 12  
PD-L1-TC    0.745    0.359
  ≥ 10% 10 8   13 5  
  < 10% 46 31   63 14  
PD-L1-IC    0.026    0.316
  ≥ 1% 22 7   25 4  
  < 1% 34 32   51 15  
Tim-3    0.040    0.245
  ≥ 1% 26 10   31 5  
  < 1% 30 29   45 14  
LAG3    0.047    0.064
  ≥ 1% 13 3   16 0  
  < 1% 43 36   60 19  
OX40    0.535    0.107
  ≥ 2% 42 27   58 11  
  < 2% 14 12   18 8  
ICOS    0.200    0.354
  ≥ 6% 29 15   37 7  
  < 6% 27 24   39 12  
IDO1-TC    0.441    0.679
  ≥ 1% 26 15   32 9  
  < 1% 30 24   44 10  
IDO1-IC    0.616    0.172
  ≥ 6% 17 10   24 3  
  < 6% 39 29   52 16  
  1. TILs tumor infiltrating lymphocytes, TC tumor cell, IC immune cell
  2. All entries in boldface are below 0.05