Biomarker | CD8 rich (n = 56) | CD8 poor (n = 39) | P value | CD4 rich (n = 76) | CD4 poor (n = 19) | P value |
---|---|---|---|---|---|---|
No. of patients | No. of patients | Â | No. of patients | No. of patients | Â | |
Foxp3 | Â | Â | 0.002 | Â | Â | 0.010 |
  ≥ 1% | 37 | 13 |  | 45 | 5 |  |
  < 1% | 19 | 26 |  | 31 | 14 |  |
CD33 | Â | Â | 0.682 | Â | Â | 0.119 |
  ≥ 1% | 38 | 28 |  | 50 | 16 |  |
  < 1% | 18 | 11 |  | 26 | 3 |  |
PD-1 | Â | Â | 0.919 | Â | Â | 0.470 |
  ≥ 1% | 25 | 17 |  | 35 | 7 |  |
  < 1% | 31 | 22 |  | 41 | 12 |  |
PD-L1-TC | Â | Â | 0.555 | Â | Â | 0.581 |
  ≥ 1% | 19 | 11 |  | 23 | 7 |  |
  < 1% | 37 | 28 |  | 53 | 12 |  |
PD-L1-TC | Â | Â | 0.745 | Â | Â | 0.359 |
  ≥ 10% | 10 | 8 |  | 13 | 5 |  |
  < 10% | 46 | 31 |  | 63 | 14 |  |
PD-L1-IC | Â | Â | 0.026 | Â | Â | 0.316 |
  ≥ 1% | 22 | 7 |  | 25 | 4 |  |
  < 1% | 34 | 32 |  | 51 | 15 |  |
Tim-3 | Â | Â | 0.040 | Â | Â | 0.245 |
  ≥ 1% | 26 | 10 |  | 31 | 5 |  |
  < 1% | 30 | 29 |  | 45 | 14 |  |
LAG3 | Â | Â | 0.047 | Â | Â | 0.064 |
  ≥ 1% | 13 | 3 |  | 16 | 0 |  |
  < 1% | 43 | 36 |  | 60 | 19 |  |
OX40 | Â | Â | 0.535 | Â | Â | 0.107 |
  ≥ 2% | 42 | 27 |  | 58 | 11 |  |
  < 2% | 14 | 12 |  | 18 | 8 |  |
ICOS | Â | Â | 0.200 | Â | Â | 0.354 |
  ≥ 6% | 29 | 15 |  | 37 | 7 |  |
  < 6% | 27 | 24 |  | 39 | 12 |  |
IDO1-TC | Â | Â | 0.441 | Â | Â | 0.679 |
  ≥ 1% | 26 | 15 |  | 32 | 9 |  |
  < 1% | 30 | 24 |  | 44 | 10 |  |
IDO1-IC | Â | Â | 0.616 | Â | Â | 0.172 |
  ≥ 6% | 17 | 10 |  | 24 | 3 |  |
  < 6% | 39 | 29 |  | 52 | 16 |  |