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Table 3 The univariate analyses and multivariate analyses for overall survival in the primary cohort

From: A nomogram-based immunoprofile predicts overall survival for previously untreated patients with esophageal squamous cell carcinoma after esophagectomy

Prognostic Factor Univariate analyses Multivariate analyses Score
HR 95% CI P HR 95% CI P
Gender
 Male 1       
 Female 1.222 0.555–2.703 0.621     
Age (years)
  < 60 1       
  ≥ 60 1.595 0.700–3.631 0.266     
History of smoking
 No 1       
 Yes 1.717 0.728–4.049 0.217     
History of drinking
 No 1       
 Yes 1.164 0.550–2.463 0.691     
AJCC TNM Stage
 I 0.039 0.007–0.212 < 0.001 0.056 0.007–0.429 0.006 0
 II 0.103 0.025–0.416 0.001 0.061 0.011–0.343 0.001 1
 III 0.181 0.047–0.690 0.012 0.088 0.020–0.391 0.001 2
 IVA     1    3
CD8
 poor 1    1    2
 rich 0.172 0.074–0.397 < 0.001 0.353 0.127–0.981 0.046 0
CD4
 poor 1    1    
 rich 0.191 0.081–0.450 < 0.001 1.199 0.431–3.337 0.729  
Foxp3
  < 1% 1    1    2
  ≥ 1% 0.327 0.147–0.726 0.006 0.215 0.080–0.582 0.002 0
CD33
  < 1% 1    1    0
  ≥ 1% 3.348 1.334–8.404 0.010 2.956 1.026–8.517 0.045 1.5
PD-1
  < 1% 1       
  ≥ 1% 0.607 0.274–1.345 0.219     
PD-L1-TC
  < 10% 1    1    0
  ≥ 10% 2.498 1.052–5.931 0.038 3.131 1.099–8.921 0.033 1.5
PD-L1-IC
  < 1% 1       
  ≥ 1% 0.858 0.376–1.954 0.715     
Tim-3
  < 1% 1    1    
  ≥ 1% 0.478 0.210–1.088 0.078 # 0.405 0.148–1.103 0.077  
LAG3
  < 1% 1       
  ≥ 1% 0.391 0.093–1.652 0.201     
OX-40
  < 2% 1       
  ≥ 2% 0.577 0.266–1.253 0.164     
ICOS
  < 6% 1       
  ≥ 6% 0.539 0.243–1.194 0.128     
IDO1-TC
  < 1% 1       
  ≥ 1% 1.410 0.671–2.962 0.364     
IDO1-IC
  < 6% 1       
  ≥ 6% 1.515 0.718–3.198 0.276     
  1. HR hazard ratio, CI confidence interval, TC tumor cell, IC immune cell, #The risk factors with P value less than 0.1 in univariable analysis were selected into multivariate analysis