Table 3 Grade 3–4 immune related adverse events divided by study arm (N = 30 patients)
Any Grade | Grade 3 | Grade 4 | Grade 3/4 Ipi 3 mg/kg | Grade 3/4 Ipi 10 mg/kg | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
No. Pts. | % | No. Pts. | % | No. Pts. | % | No. Pts. | % | No. Pts. | % | |
Adrenal insufficiency | 10 | 33 | 2 | 7 | 0 | 0 | 0 | 0 | 2 | 7 |
Hypophysitis | 2 | 7 | 2 | 7 | 0 | 0 | 0 | 0 | 2 | 7 |
Diarrhea/Colitis | 15 | 50 | 3 | 10 | 0 | 0 | 2 | 7 | 1 | 3 |
AST/ALT | 28 | 93 | 5 | 17 | 1 | 3 | 2 | 7 | 4 | 13 |
Lipase increased | 9 | 30 | 3 | 10 | 0 | 0 | 0 | 0 | 3 | 10 |
Rash, maculo-papular | 14 | 47 | 7 | 23 | 0 | 0 | 4 | 13 | 3 | 10 |
Pneumonitis | 1 | 3 | 1 | 3 | 0 | 0 | 0 | 0 | 1 | 3 |
Autoimmune nephritis | 1 | 3 | 1 | 3 | 0 | 0 | 0 | 0 | 1 | 3 |