Table 2 Adverse events experienced by at least 10% of patients by severity
AE, n (%) | Total (N = 30) | Grade 1 | Grade 2 | Grades 3 and 4 |
|---|---|---|---|---|
Any AE, highest grade experienceda | 29 (97) | 2 (7) | 8 (27) | 18 (60) |
ALT elevation | 12 (40) | 5 (17) | 5 (17) | 2 (7) |
AST elevation | 12 (40) | 7 (23) | 4 (13) | 1 (3) |
Fatigue | 11 (37) | 4 (13) | 5 (17) | 2 (7) |
Thrombocytopenia | 9 (30) | 2 (7) | 2 (7) | 5 (17) |
Nausea | 6 (20) | 2 (7) | 3 (10) | 1 (3) |
Anemia | 5 (17) | 2 (7) | 2 (7) | 1 (3) |
Hypomagnesemia | 5 (17) | 5 (17) | 0 | 0 |
Peripheral edema | 5 (17) | 3 (10) | 2 (7) | 0 |
Alkaline phosphatase elevation | 4 (13) | 3 (10) | 1 (3) | 0 |
Dysphagia | 4 (13) | 3 (10) | 0 | 1 (3) |
Dyspnea | 4 (13) | 2 (7) | 2 (7) | 0 |
Hypercalcemia | 4 (13) | 1 (3) | 2 (7) | 1 (3) |
Hypokalemia | 4 (13) | 3 (10) | 0 | 1 (3) |
Hyponatremia | 4 (13) | 3 (10) | 0 | 1 (3) |
Neutropenia | 4 (13) | 1 (3) | 0 | 3 (10) |
Vomiting | 4 (13) | 4 (13) | 0 | 0 |
Abdominal pain | 3 (10) | 1 (3) | 2 (7) | 0 |
Anorexia | 3 (10) | 1 (3) | 2 (7) | 0 |
Asthenia | 3 (10) | 1 (3) | 1 (3) | 1 (3) |
Constipation | 3 (10) | 3 (10) | 0 | 0 |
Creatinine elevated | 3 (10) | 2 (7) | 1 (3) | 0 |
Diarrhea | 3 (10) | 3 (10) | 0 | 0 |
Upper respiratory tract infection | 3 (10) | 1 (3) | 2 (7) | 0 |
Urinary tract infection | 3 (10) | 1 (3) | 2 (7) | 0 |