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Table 2 Overall Survival statistical summary

From: RAS status and neoadjuvant chemotherapy impact CD8+ cells and tumor HLA class I expression in liver metastatic colorectal cancer

Variable

Total

Univariate Cox models

Multivariate Cox models

Clinical model

Clinical and CD8 model

Clinical and HLA model

Clinical and HLA/CD8 model

Hratio

95% IC

p

adj padj padj p

Hratio

95% IC

p

adj padj padj p

Hratio

95% IC

p

adj padj padj p

Hratio

95% IC

p

adj padj padj p

Hratio

95% IC

p

adj padj padj p

Age (%)

median (range)

63 (29–83)

1.015

[0.993;1.038]

0.18

0.42

1.018

[0.995;1.041]

0.13

0.36

1.012

[0.990;1.035]

0.3

0.57

1.016

[0.993;1.040]

0.17

0.42

1.015

[0.993;1.039]

0.18

0.42

continuous

mean(sd)

61.73 (11.47)

Sex(%)

Female

33 (28.95)

1

   

1

   

1

   

1

   

1

   
 

Male

81 (71.05)

0.762

[0.469;1.238]

0.27

0.55

0.77

[0.464;1.282]

0.32

0.57

0.771

[0.460;1.292]

0.32

0.57

0.759

[0.447;1.289]

0.31

0.57

0.686

[0.397;1.185]

0.18

0.42

Chemo(%)

No

36 (31.58)

1

   

1

   

1

   

1

   

1

   
 

Yes

78 (68.42)

0.812

[0.502;1.314]

0.4

0.6

0.73

[0.432;1.231]

0.24

0.53

0.928

[0.534;1.612]

0.79

0.92

0.744

[0.438;1.262]

0.27

0.55

0.793

[0.464;1.355]

0.4

0.6

KRAS

No

79 (69.30)

1

   

–

–

–

–

 

Yes

35 (30.70)

1.979

[1.211;3.233]

0.006

0.05

BRAF+KRAS

No

76 (66.67)

1

   

1

   

1

   

1

   

1

   
 

Yes

38 (33.33)

1.737

[1.07;2.82]

0.03

0.13

2.06

[1.223;3.487]

0.007

0.05

2.171

[1.281;3.682]

0.004

0.05

1.882

[1.104;3.230]

0.02

0.1

1.716

[0.992;2.968]

0.05

0.2

Tumor side

Right

25 (21.93)

1

   

1

   

1

   

1

 

1

 

1

   
 

Left

89 (78.07)

0.92

[0.528;1.604]

0.77

0.91

1.304

[0.721;2.359]

0.38

0.6

1.151

[0.639;2.074]

0.64

0.79

1.334

[0.735;2.421]

0.34

0.58

1.208

[0.671;2.175]

0.53

0.7

CD8 invasive margin continuous

  

0.66

[0.500;0.866]

0.003

0.05

 

0.644

[0.477;0.869]

0.004

0.05

        

CD8 tumor core continuous

  

0.906

[0.679;1.209]

0.5

0.67

             

CD8 total continuous

  

0.705

[0.534;0.926]

0.01

0.06

             

HLA score

 

41 (37.27)

1

        

1

       
  

69 (62.73)

0.593

[0.366;0.959]

0.03

0.13

    

0.631

[0.379;1.050]

0.08

0.25

    

HLA/CD8 combined

Low/Low

24 (21.82)

1

               

1

   
 

Others

86 (78.18)

0.391

[0.230;0.663]

0.0005

0.02

            

0.415

[0.234;0.737]

0.003

0.05

PDL1 TC SP142

High

18

1

                
 

Low

5 (4.39)

0.6

[0.147;2.443]

0.48

0.66

            

PDL1 invasive margin SP142

High

34 (29.82)

1

                
 

Low

80 (70.18)

0.791

[0.463;1.348]

0.39

0.6

            

CD163 invasive margin

1

27 (23.68)

1

                
 

2

42 (36.84)

0.719

[0.408;1.266]

0.25

0.54

            
 

3

32 (28.07)

0.807

[0.443;1.467]

0.48

0.66

            

FoxP3 invasive margin

0

45 (39.47)

1

                
 

1

20 (17.54)

1.182

[0.654;2.135]

0.58

0.73

            

NKp46

Low

50 (49.50)

1

                   
 

High

45 (50.50)

1.024

[0.640;1.636]

0.93

0.98

                

AUC

–

–

0.63

0.72

0.67

0.72