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Fig. 5 | Journal for ImmunoTherapy of Cancer

Fig. 5

From: Immunotherapy utilizing the combination of natural killer– and antibody dependent cellular cytotoxicity (ADCC)–mediating agents with poly (ADP-ribose) polymerase (PARP) inhibition

Fig. 5

Olaparib treatment induces increased expression of gene TNFRSF10B (TRAIL-R2) in both BRCA mutant and wildtype prostate carcinoma. a Heatmap demonstrating genes modulated by at least 3-fold after olaparib treatment as identified by the NanoString nCounter® PanCancer Pathways Panel. TNFRSF10B (TRAIL-R2) was upregulated in both cell lines (by 2-fold in 22RV1 and by 20% in DU145). b Summary of modulated genes identified in NanoString analysis. c Summary of modulated genes identified in Apoptosis RT2 Profiler PCR Array with fold-change denoted in parentheses. d STRING network of protein-protein interactions of a curated set of modulated genes identified by both NanoString and apoptotic array. TNFRSF10B (TRAIL-R2; red box) identified as the nexus of both sets

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