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Table 4 Association of Baseline Blood Biomarkers and δ Changes at 8 Weeks with Overall Survival

From: Peripheral blood biomarkers correlate with outcomes in advanced non-small cell lung Cancer patients treated with anti-PD-1 antibodies

  Baseline   δ at 8 Weeks  
Biomarker HR (95% CI) N = 157 P value HR (95% CI) N = 124 P value
WBC 1.04 (1.00, 1.09) 0.043 1.18 (1.09, 1.27) < 0.001
ANC 1.05 (1.01, 1.10) 0.029 1.19 (1.10, 1.28) < 0.001
ALC 0.81 (0.53, 1.24) 0.33 0.95 (0.51, 1.76) 0.87
ANC:ALC 1.05 (1.03, 1.07) < 0.001 1.07 (1.04, 1.11) < 0.001
AMC 1.82 (1.07, 3.09) 0.027 1.45 (0.70, 3.01) 0.31
AEC 0.33 (0.07, 1.52) 0.15 1.51 (0.55, 4.10) 0.42
Platelets (per 50 unit increase) 1.08 (0.98, 1.18) 0.13 1.31 (1.12, 1.53) < 0.001
  1. HR, 95% CI and P values result from single variable (i.e. unadjusted) Cox proportional hazard models