Skip to main content

Table 4 Association of Baseline Blood Biomarkers and δ Changes at 8 Weeks with Overall Survival

From: Peripheral blood biomarkers correlate with outcomes in advanced non-small cell lung Cancer patients treated with anti-PD-1 antibodies

 

Baseline

 

δ at 8 Weeks

 

Biomarker

HR (95% CI) N = 157

P value

HR (95% CI) N = 124

P value

WBC

1.04 (1.00, 1.09)

0.043

1.18 (1.09, 1.27)

< 0.001

ANC

1.05 (1.01, 1.10)

0.029

1.19 (1.10, 1.28)

< 0.001

ALC

0.81 (0.53, 1.24)

0.33

0.95 (0.51, 1.76)

0.87

ANC:ALC

1.05 (1.03, 1.07)

< 0.001

1.07 (1.04, 1.11)

< 0.001

AMC

1.82 (1.07, 3.09)

0.027

1.45 (0.70, 3.01)

0.31

AEC

0.33 (0.07, 1.52)

0.15

1.51 (0.55, 4.10)

0.42

Platelets (per 50 unit increase)

1.08 (0.98, 1.18)

0.13

1.31 (1.12, 1.53)

< 0.001

  1. HR, 95% CI and P values result from single variable (i.e. unadjusted) Cox proportional hazard models
Back to article page