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Table 1 Mutations in primary and metastatic lesions

From: Acquired resistance to immunotherapy in MMR-D pancreatic cancer

Gene

Protein change

Mutation type

Primary Pancreas Lesion

KRAS

G12D

Missense_Mutation

RNF43

G659Vfs*41

Frame_Shift_Del

ARID1A

P1326Rfs*155

Frame_Shift_Del

STK11

P281Rfs*6

Frame_Shift_Del

B2M

S14Ffs*29

Frame_Shift_Del

MAP3K1

N1079Ifs*3

Frame_Shift_Del

ARID1A

A339Lfs*24

Frame_Shift_Del

CIC

P1529Lfs*91

Frame_Shift_Del

ERCC4

R689C

Missense_Mutation

PIK3R1

M1?

Translation_Start_Site

KMT2A

S2872*

Nonsense_Mutation

BCL2L11

S118Kfs*21

Frame_Shift_Ins

MLH1

X556_splice

Splice_Site

FANCA

P1444Rfs*3

Frame_Shift_Del

BRCA2

R2502C

Missense_Mutation

BCOR

S526 L

Missense_Mutation

BRCA2

K1191 M

Missense_Mutation

ALK

G1202Efs*56

Frame_Shift_Del

ZFHX3

A3407Lfs*78

Frame_Shift_Del

PTPRS

R1102H

Missense_Mutation

FLT1

R1305H

Missense_Mutation

AR

R280C

Missense_Mutation

ROS1

R1592C

Missense_Mutation

JAK3

P84Rfs*63

Frame_Shift_Del

PTPRT

I502T

Missense_Mutation

RECQL4

V155Sfs*25

Frame_Shift_Del

VTCN1

Y145H

Missense_Mutation

RAF1

Y458F

Missense_Mutation

SETD2

D1057N

Missense_Mutation

GATA2

P385S

Missense_Mutation

APC

R259Q

Missense_Mutation

APC

T1932A

Missense_Mutation

ARID1B

G314R

Missense_Mutation

ARID1B

A1002V

Missense_Mutation

RECQL4

G1166S

Missense_Mutation

RECQL4

A33V

Missense_Mutation

PAX5

R38C

Missense_Mutation

TGFBR1

V229D

Missense_Mutation

H3F3C

M120 V

Missense_Mutation

KMT2D

S1555F

Missense_Mutation

CREBBP

P2311L

Missense_Mutation

ZFHX3

T2667A

Missense_Mutation

PLCG2

L631R

Missense_Mutation

SPOP

N196K

Missense_Mutation

STK11

L285R

Missense_Mutation

INSR

R279H

Missense_Mutation

MEF2B

P106H

Missense_Mutation

TOP1

I457T

Missense_Mutation

NF2

K469R

Missense_Mutation

AR

V139M

Missense_Mutation

TRAF7

N174del

In_Frame_Del

Metastatic Site: Ovary/Endometrium

KRAS

G12D

Missense_Mutation

RNF43

G659Vfs*41

Frame_Shift_Del

TSC2

Q35*

Nonsense_Mutation

TP53

R273C

Missense_Mutation

STK11

X245_splice

Splice_Site

PBRM1

P1411Lfs*21

Frame_Shift_Del

BARD1

K208Rfs*4

Frame_Shift_Del

ATRX

D1940Ifs*15

Frame_Shift_Del

KMT2D

K4318Efs*15

Frame_Shift_Del

KMT2B

G1879Vfs*16

Frame_Shift_Del

NRAS

A66V

Missense_Mutation

CIC

R440H

Missense_Mutation

INSR

R1331C

Missense_Mutation

MYCN

R285Q

Missense_Mutation

BCL6

S434 N

Missense_Mutation

TNFAIP3

K759Qfs*10

Frame_Shift_Ins

RPS6KA4

RPS6KA4-BAD fusion

Fusion

FLT3

S188R

Missense_Mutation

ERBB2

H193N

Missense_Mutation

DOT1L

V170 L

Missense_Mutation

PTPRT

E917V

Missense_Mutation

HIST1H3F

T119A

Missense_Mutation

INHBA

A41T

Missense_Mutation

RXRA

G73C

Missense_Mutation

ARAF

E556G

Missense_Mutation

BAD

RPS6KA4-BAD fusion

Fusion