Fig. 2From: Soluble immune checkpoints in cancer: production, function and biological significanceThe role of sPD-1 between APCs and T cells. Some studies have demonstrated that when sPD-1 binds to PD-L1 in APCs, it can induce a reverse signal that acts on APCs and inhibits T cell function. However, other experiments have found that the existence of PD-L1/sPD-1 enhances the function of T cells. T cells can be activated with the anti-PD-L1-mAbBack to article page