Fig. 4

Comparison of T cell receptor clonality by viral status and response to anti-PD-1. a) TCR clonality is significantly higher in patients with VP-MCCs compared to those with VN-MCCs (p = 0.0001 by Mann-Whitney test). b) TCR clonality is not associated with response to pembrolizumab (p = 0.2636 by Mann-Whitney test). This observation remains true when comparing clonality among responding versus non-responding patients whose tumors are virus-positive (virus(+) = open circles; virus(−) = black squares)