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Fig. 2 | Journal for ImmunoTherapy of Cancer

Fig. 2

From: Tumor-derived exosomal HMGB1 fosters hepatocellular carcinoma immune evasion by promoting TIM-1+ regulatory B cell expansion

Fig. 2

TIM-1+B cells are a regulatory B cell subset that exhibits a unique phenotype and function. a Flow cytometry analysis of the phenotypic characteristics of the TIM-1+B cells from the paired blood, liver tissue and HCC tissue samples (n = 10). b Analysis of the representative markers expressed by tumor-infiltrating TIM-1+ and TIM-1B cells. c Flow cytometry analysis of the TNF-α and IFN-γ production of the tumor-infiltrating CD8+ effector T cells cocultured with tumor-infiltrating TIM-1+ B cells or TIM-1 B cells. d Flow cytometry analysis of the TNF-α and IFN-γ production of CD8+ effector T cells in the tumor-infiltrating lymphocytes (TILs) and TILs without TIM-1+B cells groups. c-d The data are represented as the mean ± s.e.m. of three independent experiments. e Associations between tumor-infiltrating IFN-γ+CD8+ T cells and tumor-infiltrating TIM-1+B cells (n = 9). *P < 0.05, **P < 0.01, and ***P < 0.001

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