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Fig. 7 | Journal for ImmunoTherapy of Cancer

Fig. 7

From: Tumor cell-released autophagosomes (TRAPs) promote immunosuppression through induction of M2-like macrophages with increased expression of PD-L1

Fig. 7

Proposed schematic model depicting the role of TRAPs in macrophage polarization and adaptive immune suppression. TRAPs are uptaken by macrophages and promotes MyD88-p38-STAT3 activation via TLR4, leading to upregulation of PD-L1 and IL-10 that is responsible for inhibition of cytotoxic T lymphocytes (CTLs) activation, and in turn enhancing tumor progression

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