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Table 2 Immune Profiling and Data Sharing Projects Presented at the SITC Workshop

From: SITC 2018 workshop report: Immuno-Oncology Biomarkers: State of the Art

Name of Project Institution Approach
Tumor Neoantigen Selection Alliance (TESLA) Parker Institute for Cancer Immunotherapy Support efforts to develop safe and effective neoantigen vaccines through effective neo-epitope prediction algorithms and high-quality epitope validation sets.
MANAFEST Johns Hopkins Bloomberg-Kimmel Institute for Cancer Immunotherapy An assay that combines whole exome sequencing, T cell receptor sequencing, and bioinformatics to identify targetable mutation-associated neoantigens.
APOLLO MD Anderson Cancer Center Biomarker discovery by analyzing tissue samples collected during pre-treatment, treatment and progression.
ECOG 1608 Biomarker project Sidra Medicine Doha and ECOG-ACRIN Combination of cellular immune monitoring assays, in vitro stimulation, protein profiling, genotyping, and transcriptomic analysis of PBMCs to estimate the proportion and functional orientation of immune cell subtypes.
Immunoscore/Immunoprofiling Society for Immunotherapy of Cancer (SITC) Objectively measure tumor immune infiltrates using digital imaging technology to demonstrate correlations with patient prognosis. Develop standards for next generation multiplex assays.
IBEX (Iterative Bleaching Extends Multi-pleXity) National Institutes of Health An iterative staining method detecting more than 40 protein markers to highlight immune-tumor interactions.
Peptide MHC tetramer staining Agency for Science, Technology and Research To identify antigen-specific T cells while preserving phenotypic profiles, and without requiring in vitro expansion.
Multiplexed ion beam imaging (MIBI) Stanford University Determine what cell phenotypes are present in a sample, how the discovered phenotypes are spatially distributed relative to one another, and how identified phenotypes are related to a disease state.
1000 Immunomes Project (1KIP) Stanford University A systems biology approach to the discovery of biomarkers associated with systemic chronic inflammation.
Neoantigen Fitness Model Icahn School of Medicine A mechanistic model representing the process of immune cell neoantigen recognition to predict tumor response to therapy.
imCORE global network Genentech Centralized testing of samples for data quality monitoring and public access to standardized clinical trial data.
Project GENIE (Genomics Evidence Neoplasia Information Exchange) American Association for Cancer Research (AACR) An international cancer registry that links clinical genotypes to patient outcomes.
Oncology Research Information Exchange Network (ORIEN) M2Gen A cancer center alliance based on the common use of the Total Cancer Care (TCC) protocol to accelerate cancer discovery through collaborative learning, partnership and data sharing.
Sparkathon Project TimIOs Society for Immunotherapy of Cancer (SITC) Cross-study analysis of patient response to help further the understanding of tumor heterogeneity in treating patients with immunotherapy.