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Fig. 2 | Journal for ImmunoTherapy of Cancer

Fig. 2

From: Novel TLR2-binding adjuvant induces enhanced T cell responses and tumor eradication

Fig. 2

AV retains its superior capacity in induction of DC maturation over Pam3CSK4 upon conjugation. (A – C) Concentration of IL-12p40 in the supernatant of BMDCs stimulated overnight with ovalbumin-derived SLPOVA CTL or SLPOVA Th or HPV16 E7-derived SLPHPV, conjugated to either Pam3CSK4 or AV. (D-F) Expression of CD86 (MFI; mean fluorescence intensity) on BMDCs stimulated overnight as in Fig. 2a, B and c. Results are representative of at least three independently performed experiments with each of the conjugated SLPs. Significance determined by unpaired t-test: * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001

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