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Fig. 5 | Journal for ImmunoTherapy of Cancer

Fig. 5

From: Novel TLR2-binding adjuvant induces enhanced T cell responses and tumor eradication

Fig. 5

Combination of AV-SLPHPV conjugate vaccination and immunomodulatory therapy in TC-1 tumor model. (A) Overview of experimental setup (timelines). Numbers indicate number of days after tumor challenge. (B) Tumor growth curves and Kaplan-Meier survival plot of combination treatment of AV-SLPHPV conjugate vaccination and i.p. cisplatin treatment. Numbers in graph indicate number of cured mice of total in group. Results are shown of one of two experiments with similar outcome. (C) Combination treatment of AV-SLPHPV conjugate vaccination and photodynamic therapy (PDT). Tumor growth curves and Kaplan-Meier survival plots of groups of mice carrying a TC-1 tumor vaccinated with indicated vaccines. Bottom Kaplan-Meier plot represents survival of mice after re-challenge with TC-1 tumor cells at day 55. Significance determined by log-rank test; * p < 0.05; ** p < 0.01; *** p < 0.001

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