Table 2 In vitro proliferation assays with PI3K inhibitors in CT-26 and 4 T1 cell lines does not suggest in vivo efficacy by direct effect in tumor cells
Incucyte proliferation data IC50 (μM) | |||
|---|---|---|---|
Inhibitor | Target | 4 T1 | CT26 |
Mean IC50 | Mean IC50 | ||
AZD8835 | PI3Kα/δ | 13.913 | 4.591 |
AZD8186 | PI3Kβ/δ | > 30 | 14.597 |
GDC-0941 | Pan-PI3K | 5.004 | 0.486 |
PI-3065 | PI3Kδ | 5.61 | 9.27 |