Table 3 Current and recently completed trials using oncolytic viruses

Herpes Simplex Virus I

Talimogene Laherparepvec (T-Vec)

Amgen

I/II

Breast

Adjuvant

II

Melanoma

Primary

I

Pancreatic

Primary

TBI-1401(HF10)

Takara

I

Superficial Solid Tumors

Primary

II

Melanoma

Adjuvant

G207

MediGene

Ib/II

Glioma

Primary

HSV1716

Virtu Biologics

I/II

Mesothelioma

Primary

I

Bone, Sarcomas, Neuroblastomas

Primary

Adenovirus/Herpes Simplex Virus

ADV/HSV-tk

Merck

II

Breast and NSCLC

Adjuvant

Adenovirus

LOAd703

Lokon

I/II

Pancreatic

Adjuvant

CG0070

Cold Genesys

II

Bladder

Primary

ColoAd1(Enadenotucirev)

PsiOxus

I

Colorectal, NSCLC, Bladder, and Renal Cell

Primary

I/II

Colorectal, Bladder, and Epithelial

Primary

I

Ovarian

Primary

ONCOS-102

Targovax Oy

I

Advanced Solid Tumors

Adjuvant

I

Melanoma

Adjuvant

DNX-2401

DNAtrix

II

Brain

Adjuvant

VCN-01

VCN

I

Advanced Solid Tumors

Adjuvant

I

Pancreatic

Adjuvant

Ad-MAGEA3 and MG1-MAGEA3

Turnstone

I/II

NSCLC

Adjuvant

I/II

Advanced Solid Tumors

Primary

NSC-CRAd-Survivin-pk7

Northwestern

I

Glioma

Adjuvant

Ad5-yCD/mutTKSR39rep-hIL12

Henry Ford

I

Prostate

Adjuvant

Ad5-yCD/mutTKSR39rep-ADP

Henry Ford

I

NSCLC

Primary

Measles

MV-NIS

Mayo

I

Breast and Head and Neck

Primary

I/II

Ovarian

Primary

I

Nerve Sheath

Primary

I

Mesothelioma

Primary

I/II

Multiple Myeloma

Adjuvant

MV-NIS

University of Arkansas

II

Multiple Myeloma

Adjuvant

Vaccinia

GL-ONC1

Genelux

I

Advanced Solid Tumors

Primary

I

Head and Neck

Primary

Ib

Advanced Solid Tumors

Adjuvant

I

Ovarian

Primary

Pexastimogene Devacirepvec (Pexa-Vec)

Jennerex

III

Hepatocellular

Adjuvant

I/IIa

Colorectal

Adjuvant

I

Advanced Solid Tumors

Adjuvant

I

Blue Cell

Primary

I

Melanoma, Lung, Renal Cell, Head and Neck

Primary

Reovirus

REOLYSIN

Oncolytics

I

Colorectal

Adjuvant

Ib

Bladder

Adjuvant

Ib

Pancreatic

Adjuvant

I

Multiple Myeloma

Adjuvant

Ib

Plasma Cell Cytoma

Adjuvant

II

Ovarian and Peritoneal

Adjuvant

Coxsackievirus

CVA21(CAVATAK)

Viralytics

II

Melanoma

Primary

I

NSCLC

Adjuvant

Parvovirus

H-1PV(ParvOryx)

Oryx GmbH

I/IIa

Glioblastoma Multiforme

Primary

Polio/Rhinovirus

PVSRIPO

Duke

I

Glioma

Primary

Vesicular Stomatitis Virus

VSV-hIFNbeta-NIS

Mayo

I

Endometrial

Primary