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Table 3 Current and recently completed trials using oncolytic viruses

From: Oncolytic virus immunotherapy: future prospects for oncology

Virus Strain Manufacturer Phase Targeted Malignancy Primary or Adjuvant Therapy
Herpes Simplex Virus I Talimogene Laherparepvec (T-Vec) Amgen I/II Breast Adjuvant
II Melanoma Primary
I Pancreatic Primary
TBI-1401(HF10) Takara I Superficial Solid Tumors Primary
II Melanoma Adjuvant
G207 MediGene Ib/II Glioma Primary
HSV1716 Virtu Biologics I/II Mesothelioma Primary
I Bone, Sarcomas, Neuroblastomas Primary
Adenovirus/Herpes Simplex Virus ADV/HSV-tk Merck II Breast and NSCLC Adjuvant
Adenovirus LOAd703 Lokon I/II Pancreatic Adjuvant
CG0070 Cold Genesys II Bladder Primary
ColoAd1(Enadenotucirev) PsiOxus I Colorectal, NSCLC, Bladder, and Renal Cell Primary
I/II Colorectal, Bladder, and Epithelial Primary
I Ovarian Primary
ONCOS-102 Targovax Oy I Advanced Solid Tumors Adjuvant
I Melanoma Adjuvant
DNX-2401 DNAtrix II Brain Adjuvant
VCN-01 VCN I Advanced Solid Tumors Adjuvant
I Pancreatic Adjuvant
Ad-MAGEA3 and MG1-MAGEA3 Turnstone I/II NSCLC Adjuvant
I/II Advanced Solid Tumors Primary
NSC-CRAd-Survivin-pk7 Northwestern I Glioma Adjuvant
Ad5-yCD/mutTKSR39rep-hIL12 Henry Ford I Prostate Adjuvant
Ad5-yCD/mutTKSR39rep-ADP Henry Ford I NSCLC Primary
Measles MV-NIS Mayo I Breast and Head and Neck Primary
I/II Ovarian Primary
I Nerve Sheath Primary
I Mesothelioma Primary
I/II Multiple Myeloma Adjuvant
MV-NIS University of Arkansas II Multiple Myeloma Adjuvant
Vaccinia GL-ONC1 Genelux I Advanced Solid Tumors Primary
I Head and Neck Primary
Ib Advanced Solid Tumors Adjuvant
I Ovarian Primary
Pexastimogene Devacirepvec (Pexa-Vec) Jennerex III Hepatocellular Adjuvant
I/IIa Colorectal Adjuvant
I Advanced Solid Tumors Adjuvant
I Blue Cell Primary
I Melanoma, Lung, Renal Cell, Head and Neck Primary
Reovirus REOLYSIN Oncolytics I Colorectal Adjuvant
Ib Bladder Adjuvant
Ib Pancreatic Adjuvant
I Multiple Myeloma Adjuvant
Ib Plasma Cell Cytoma Adjuvant
II Ovarian and Peritoneal Adjuvant
Coxsackievirus CVA21(CAVATAK) Viralytics II Melanoma Primary
I NSCLC Adjuvant
Parvovirus H-1PV(ParvOryx) Oryx GmbH I/IIa Glioblastoma Multiforme Primary
Polio/Rhinovirus PVSRIPO Duke I Glioma Primary
Vesicular Stomatitis Virus VSV-hIFNbeta-NIS Mayo I Endometrial Primary