Table 1 Patient clinical characteristics (n = 28)
Characteristic | No. of patients (%) |
|---|---|
Mean age, years (SD) | 63 (10) |
Male sex | 20 (71) |
Cancer type | |
Melanoma | 7 (25) |
Renal cell carcinoma | 4 (14) |
Prostate carcinoma | 4 (14) |
Urothelial | 3 (11) |
Other solid tumors | 10 (36) |
Cancer stage | |
III | 6 (21) |
IV | 22 (79) |
ICI type | |
CTLA-4 | 8 (29) |
PD-1/L1 | 12 (43) |
Combination | 8 (29) |
Median no. of ICI infusions (IQR) | 3 (1–36) |
Median time to diarrhea onset, weeks (IQR) | 10 (1–70) |
Peak CTCAE grade of diarrhea | |
2 | 15 (54) |
3–4 | 13 (46) |
Peak CTCAE grade of colitis | |
1–2 | 16 (57) |
3–4 | 12 (43) |
Colitis symptoms | |
Abdominal pain | 14 (50) |
Blood or mucous in stool | 11 (39) |
Other adverse events | |
Dermatological | 4 (14) |
Endocrine | 2 (7) |
Musculoskeletal | 2 (7) |
Pulmonary | 1 (4) |
Pancreatic | 1 (4) |