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Table 2 Patient diagnostic evaluation data (n = 28)

From: Outcomes of vedolizumab therapy in patients with immune checkpoint inhibitor–induced colitis: a multi-center study

Characteristic

No. of patients (%)

Endoscopy and histologic features

 Type of endoscopy

  Colonoscopy

22 (79)

  Flexible sigmoidoscopy

6 (21)

 Endoscopic findings on initial evaluation

  Ulceration

8 (29)

  Nonulcerative inflammation

13 (46)

  Normal

7 (25)

 Endoscopic distribution

  Extensive

14 (50)

  Left colon only

5 (18)

  Isolated small bowel

2 (7)

 Histological inflammation on initial evaluation

  Active features

28 (100)

  Chronic features

14 (50)

  Microscopic

10 (36)

  Median no. of endoscopic procedures (IQR)

2 (1–7)

 Diagnostic laboratory studies

  Mean duration of laboratory follow-up, months (SD)

3 (4)

  Positive fecal lactoferrin at onset of diarrheaa

23 (100)

  Positive fecal lactoferrin after vedolizumab therapyb

11 (79)

  Mean fecal calprotectin value at onset of diarrhea μg/g (SD)c

329 (276)

Mean fecal calprotectin value at follow-up μg/g (SD)d

218 (262)

  1. Abbreviations: IQR, interquartile range; SD, standard deviation.
  2. aLactoferrin was initially measured for 23 patients
  3. bLactoferrin was measured at follow-up for 14 patients
  4. cCalprotectin was initially measured for 19 patients
  5. dCalprotectin was measured at follow-up for 13 patients