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Fig. 3 | Journal for ImmunoTherapy of Cancer

Fig. 3

From: Activity of durvalumab plus olaparib in metastatic castration-resistant prostate cancer in men with and without DNA damage repair mutations

Fig. 3

Early Markers of Response Are Associated with Progression-Free Survival. a Kaplan-Meier curve showing that patients with <= median percentage of MDSCs at baseline had prolonged PFS. b Change in CTC numeration from C1D1 to C3D1. c Decrease or no change in in CTC count from C1D1 to C1D15 correlated with increased PFS. d Kaplan-Meier curve demonstrating that increased DC maturity (as demonstrated by CD83 expression on CD141+ mDCs from baseline to C1D15) was associated with prolonged PFS. e Kaplan-Meier curve demonstrating that patients with > median percentage of K67+PD−1+CD8+ T cells among total CD8+ T cells at C1D15 had prolonged PFS. f Kaplan-Meier curve demonstrating that patients with > median percentage of K67+PD− 1+CD4+ T cells among total CD4+ T cells at C3D1 had prolonged PFS

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