Adverse Event | Grade 1 | Grade 2 | Grade 3 | Grade 4 |
---|---|---|---|---|
Hematology | ||||
 Anemia | 3 | 2 | 4 | 0 |
 Leukopenia | 4 | 1 | 1 | 0 |
 Lymphopenia | 0 | 2 | 1 | 1 |
 Neutropenia | 0 | 0 | 1 | 0 |
 Thrombocytopenia | 3 | 0 | 1 | 0 |
Gastrointestinal Disorders | ||||
 Abdominal pain | 1 | 0 | 0 | 0 |
 Anorexia | 1 | 1 | 0 | 0 |
 AST increased | 1 | 0 | 0 | 0 |
 Bloating | 0 | 1 | 0 | 0 |
 Dysgeusia | 0 | 1 | 0 | 0 |
 Dyspepsia | 2 | 0 | 0 | 0 |
 Diarrhea | 6 | 3 | 0 | 0 |
 Nausea | 8 | 1 | 2 | 0 |
 Oral mucositis | 0 | 1 | 1 | 0 |
 Vomiting | 6 | 0 | 1 | 0 |
Cardiovascular | ||||
 Hypertension | 0 | 0 | 1 | 0 |
Infection | ||||
 Lung | 0 | 0 | 1 | 0 |
 Tenosynovitis | 0 | 0 | 1 | 0 |
 Urinary tract | 0 | 1 | 0 | 0 |
Endocrine and Chemistry | ||||
 Hypothyroidism | 0 | 1 | 0 | 0 |
Nervous System | ||||
 Dizziness | 1 | 0 | 0 | 0 |
 Headache | 1 | 0 | 0 | 0 |
 Paresthesia | 1 | 0 | 0 | 0 |
 Syncope | 0 | 0 | 1 | 0 |
Respiratory, Thoracic, and Mediastinal | ||||
 Dyspnea | 1 | 0 | 0 | 0 |
 Cough | 1 | 1 | 0 | 0 |
Eye Disorders | ||||
 Blurred vision | 1 | 0 | 0 | 0 |
 Optic nerve disorder | 0 | 1 | 0 | 0 |
Ear and Labyrinth Disorders | ||||
 Hearing impairment | 0 | 1 | 1 | 0 |
 Tinnitus | 1 | 0 | 0 | 0 |
General | ||||
 Fatigue | 1 | 2 | 1 | 0 |
 Edema, limbs | 1 | 0 | 0 | 0 |
 Localized edema | 1 | 0 | 0 | 0 |
 Pain, extremity | 0 | 1 | 0 | 0 |
 Weight loss | 1 | 0 | 0 | 0 |
Musculoskeletal and Connective Tissue | ||||
 Arthralgia | 2 | 0 | 0 | 0 |
 Arthritis | 0 | 1 | 0 | 0 |
 Myalgia | 2 | 0 | 0 | 0 |
 Musculoskeletal/connective tissue, leg cramps | 1 | 1 | 0 | 0 |
 Musculoskeletal/connective tissue, muscle cramps | 0 | 0 | 1 | 0 |
 Muscle weakness, lower limb | 0 | 0 | 1 | 0 |
Skin, Subcutaneous Tissue | ||||
 Erythema | 1 | 0 | 0 | 0 |
 Pruritis | 1 | 0 | 0 | 0 |
 Rash, maculopapular | 2 | 0 | 0 | 0 |
Metabolism and Nutrition | ||||
 Dehydration | 0 | 1 | 0 | 0 |