Skip to main content
Fig. 1 | Journal for ImmunoTherapy of Cancer

Fig. 1

From: A novel anti-HER2 anthracycline-based antibody-drug conjugate induces adaptive anti-tumor immunity and potentiates PD-1 blockade in breast cancer

Fig. 1

T-PNU strongly affects tumor growth in hHER2 orthotopic breast cancer model unresponsive to T-DM1 treatment. a, Therapeutic response of EMT6-hHER2 tumor-bearing mice following treatment with T-PNU (1 mg/kg, 2x) and T-DM1 (15 mg/kg, 2x). Mice were treated when tumors reached an average tumor volume of 80 mm3 and were euthanized at 1200 mm3. Pooled data from at least three independent experiments (n = number of cured mice out of treated animals as indicated). b, Overall survival curves showing results of a. c, Therapeutic response of EMT6-WT tumor-bearing mice following treatment with T-PNU (1 mg/kg, 2x). Pooled data from two independent experiments (n = number of cured mice out of treated animals as indicated. d, Overall survival curves showing results of c

Back to article page