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Fig. 3 | Journal for ImmunoTherapy of Cancer

Fig. 3

From: Cutaneous adverse reactions in B-RAF positive metastatic melanoma following sequential treatment with B-RAF/MEK inhibitors and immune checkpoint blockade or vice versa. A single-institutional case-series

Fig. 3

Skin biopsy of rash with histology. a Skin biopsy shows slight basal layer vacuolization, dermal edema and a superficial dermal perivascular lymphocyte and eosinophil infiltrate. No necrosis is present. (H&E, 200X). b Eosinophils (arrows) are present with lymphocytes around the superficial dermal capillaries fibrinoid necrosis of capillary walls, a sign of vasculitis, is not present. (H&E, 400X)

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