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Table 1 In vitro drug response of MLH1−/− cell lines

From: Chemo-immunotherapy improves long-term survival in a preclinical model of MMR-D-related cancer

Drug IC50 value [μM]
MLH1−/− A7450 T1 M1a MLH1−/−  328 MLH1−/−  1351
GEM 0.05 0.07 < 0.02
Cisplatin 0.63 0.05 0.06
5-FU 2.15 3.57 1.00
CPX > 300 > 300 > 300
  1. GEM Gemcitabin, 5-FU 5-Fluorouracil, CPX Cyclophosphamide; a [18]