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Table 2 Effect on prophylactic chemo-immunotherapy on tumorigenesis and tumor spectrum in MLH1−/− mice

From: Chemo-immunotherapy improves long-term survival in a preclinical model of MMR-D-related cancer

Intervention mean age of onset [weeks ± SD] tumor type [%] mice [%]
Lymphoma GIT Lymphoma GIT other tumor free
controla 25.3 ± 11.7 35.5 ± 9.3 62.1 34.7 3.2 0.0
lysate 30.2 ± 10.0 47.4 ± 8.5 51.7 33.3 0.0 15.0
GEM + vaccine 23.5 ± 13.4 53.4 ± 14.1 22.2 44.4 0.0 33.3
CPX + vaccine 34.3 ± 6.9 47.7 ± 5.9 55.5 33.3 0.0 11.1
  1. aGEM and CPX treated mice without vaccine were grouped together, GIT gastrointestinal tumor