Source | PD-(L)1 Drugb | Histology | No. of patientsa | Median age (years)a | Male (%)a | Performance statusa | PD-L1 subgroupsa | ||||
---|---|---|---|---|---|---|---|---|---|---|---|
ITT | As treated | ECOG 0 (%) | ECOG 1 (%) | <1% (%) | 1–49% (%) | ≥50% (%) | |||||
KEYNOTE-189 2018 [6] | Pembrolizumab | nonsquamous | 410 vs 206 | 405 vs 202 | 65 vs 64 | 62 vs 53 | 45 vs 39 | 54 vs 61 | 31 vs 31 | 31 vs 28 | 32 vs 34 |
IMpower150 2018 [15] | Atezolizumab | nonsquamous | 400 vs 400 | 393 vs 394 | 63 vs 63 | 60 vs 60 | 39 vs 43 | 60 vs 57 | 47 vs 50 | 33 vs 31 | 20 vs 19 |
Pembrolizumab | nonsquamous | 60 vs 63 | 59 vs 62 | 63 vs 63 | 37 vs 41 | 40 vs 46 | 58 vs 54 | 35 vs 37 | 32 vs 37 | 33 vs 27 | |
KEYNOTE-407 2018 | Pembrolizumab | squamous | 278 vs 281 | 278 vs 280 | 65 vs 65 | 79 vs 84 | 26 vs 32 | 74 vs 68 | 34 vs 35 | 37 vs 37 | 26 vs 26 |
IMpower131 2018 [17] | Atezolizumab | squamous | 343 vs 340 | 334 vs 334 | 65 vs 65 | 81 vs 82 | 34 vs 32 | 66 vs 68 | 47 vs 50 | 38 vs 36 | 15 vs 14 |
CheckMate 227 2018 [18] | Nivolumab | suqamous and nonsquamous | 177 vs 186 | 172 vs 185 | 64 vs 64 | 73 vs 67 | 33 vs 31 | 66 vs 68 | 100 vs 100 | 0 vs 0 | 0 vs 0 |