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Fig. 4 | Journal for ImmunoTherapy of Cancer

Fig. 4

From: Nephrotoxicity of immune checkpoint inhibitors beyond tubulointerstitial nephritis: single-center experience

Fig. 4

In the case of amyloidosis, the glomeruli showed diffuse mesangial expansion by amorphous eosinophilic matrix, indicated by arrows (a, H&E) that showed green birefringence under polarized light by Congo red stain (b) and diffuse 3+ fluorescence (Thioflavin T stain) of deposits in glomeruli and arterioles (c). Abundant fibrils measuring 8–10 nm were identified by electron microscopy, area of dense fibril deposition within the box, less dense fibril deposition indicated by arrows (d)

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