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Fig. 2 | Journal for ImmunoTherapy of Cancer

Fig. 2

From: A severe case of refractory esophageal stenosis induced by nivolumab and responding to tocilizumab therapy

Fig. 2

Morphological examination of oropharynx biopsies showed marked lymphocytic inflammation of the submucosa (a, original magnification × 40) with infiltration of the epithelial layer, where scattered apoptotic cells were observed (b, original magnification × 200). Immunohistochemical staining revealed that a minor population of lymphocytes (about 10%) was CD20 positive (c, original magnification × 100), while the majority of lymphocytic infiltration (about 90%) was represented by CD3-positive T-cells (d, original magnification × 100). Among T-lymphocytes, about 80% were CD4 positive (e, original magnification × 100) and about 20% were CD8 positive (f, original magnification × 100)

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