Fig. 3

Genomic correlates of response to immune checkpoint inhibitor (ICI) therapy in a subset of 8 patients with metastatic MITF family translocation renal cell carcinoma (tRCC). The identified mutations and mutational load were assessed by either whole-exome sequencing or targeted sequencing. Numbers of mutations and genes mutated in each sample are given. a Genes mutated in the 4 samples assessed by whole-exome sequencing. b Box-plots depicting mutational load in tRCC patients (n = 4) assessed by whole-exome sequencing as compared to that in patients with clear-cell RCC (ccRCC) from the TCGA dataset (n = 420). c Genes mutated in the 4 samples assessed by targeted sequencing