Fig. 4

Genomic evolution of a tumor from a patient who had an exceptional response to ipilimumab. a Numbers of somatic mutations in the primary tumor and in the 2 resistant clones following ipilimumab treatment reveal an increase of mutational load. Blue indicates shared mutations across all 3 samples; orange indicates private mutations. b String network analysis of 17 genes showing parallel evolution reveals 5 genes (in red) linked to the O-glycosylation process. c List of somatic mutations in the primary tumor and resistant clones showing mutations lost in resistant clones as compared to primary tumor and mutations in genes with parallel evolution