Skip to main content


Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

Fig. 4 | Journal for ImmunoTherapy of Cancer

Fig. 4

From: Immune checkpoint inhibitors in MITF family translocation renal cell carcinomas and genetic correlates of exceptional responders

Fig. 4

Genomic evolution of a tumor from a patient who had an exceptional response to ipilimumab. a Numbers of somatic mutations in the primary tumor and in the 2 resistant clones following ipilimumab treatment reveal an increase of mutational load. Blue indicates shared mutations across all 3 samples; orange indicates private mutations. b String network analysis of 17 genes showing parallel evolution reveals 5 genes (in red) linked to the O-glycosylation process. c List of somatic mutations in the primary tumor and resistant clones showing mutations lost in resistant clones as compared to primary tumor and mutations in genes with parallel evolution

Back to article page