Fig. 2

CTX/L-NIL combines with CRT to induce durable control of established tumors. Mice bearing established mEER tumors were treated with CRT (10 X 3Gy tumor-directed radiation and 83 μg/mouse weekly cisplatin i.p.) and/or CTX/L-NIL immunomodulation (CTX at 2 mg/mouse i.p. and L-NIL at 0.2% in drinking water) according to the schedule in (a); mice were euthanized when tumors reached 225 mm². b Individual tumor growth curves shown by treatment group, with each mouse represented as a single line. c Average tumor area (top) and statistical comparison at time of first euthanasia (bottom; Tukey’s multiple comparison test). d Survival curves (top) and statistical comparison between treatments (bottom; Log-rank test). (b-d; N = 1 representative of 2; n = 8–9/group). **p < 0.01; ***p < 0.001; ****p < 0.0001; ns, not significant