Fig. 6

Tumor growth inhibition induced by CRT + CTX/L-NIL requires CD8⁺ T cells. Established mEER tumors were treated with CRT + CTX/L-NIL and anti-CD8α depleting antibody, or isotype control antibody, according to the schedule in (a); mice were euthanized when tumors reached 225 mm². b CD8⁺ T cell percentages among total viable cells in the blood at day 29 of treatment as assessed by flow cytometry (N = 1; n = 10/group, each as an individual dot; data are means +/− SD; Mann-Whitney test). c Individual tumor growth curves shown by treatment group, with each mouse represented as a single line. d Average tumor area (top) and statistical comparison at time of first euthanasia (bottom; Tukey’s multiple comparison test). e Survival curves (top) and statistical comparison between treatments (bottom; Log-rank test). (c-e; N = 1 representative of 2; n = 10/group). *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001; ns, not significant