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Fig. 5 | Journal for ImmunoTherapy of Cancer

Fig. 5

From: Hyperspectral cell sociology reveals spatial tumor-immune cell interactions associated with lung cancer recurrence

Fig. 5

Patient-level comparison of cell sociology compared to density measurements in the prediction of recurrence. Each column represents an individual patient and recurrence status is represented as blue (non-recurrent) and orange (recurrent). The ability of cell density metrics for CD3+ CD8- T cells, CD79a+ cells, and CD3+ CD8+ T cells to correctly classify patient recurrence status by at least one ROI is represented in light blue (non-recurrent) and light orange (recurrent). Patients correctly classified by any cell density metric are indicated in green and those incorrectly classified in grey. For each patient ROI, the benefit of assessing cell sociology of tumor cells with immune cells (CD3+ CD8-, CD3+ CD8+, and CD79a) was compared to density performance. Classification enrichment in the non-recurrent direction is indicated in blue and in the recurrent direction in orange, while equivalent performance as compared to density is indicated in light blue (non-recurrent) and light orange (recurrent). Patients with an overall improvement in classification by cell sociology are indicated in green, those with no change are indicated in yellow, and those misclassified by cell sociology are indicated in red

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