Fig. 7

Graphical depiction of how intracellular accumulation could mechanistically improve tumor colonization. a) When Salmonella have a low intracellular accumulation rate, the rate of dispersion back into tumor vasculature is high, thus reducing bacterial tumor colonization due to a lack of “binding” to cancer cells. b) When Salmonella have a high intracellular accumulation rate, more bacteria would be retained in the tumor and not leak back into tumor microvasculature, thus increasing overall tumor colonization.