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Fig. 2 | Journal for ImmunoTherapy of Cancer

Fig. 2

From: Different role of circulating myeloid-derived suppressor cells in patients with multiple myeloma undergoing autologous stem cell transplantation

Fig. 2

Suppressive function of pre- and post-ASCT MDSC phenotypes. We isolated E- and M-MDSC phenotypes from six patients’ PBMCs collected pre- and post-ASCT and tested autologous CD4, CD8 T-, and NKT-cell suppression mediated by each MDSC phenotype. The top figures are representative and individual data from independent experiments using MDSC phenotypes isolated from the six patients, as shown in the bottom figure. Both pre-ASCT E- and M-MDSC subsets had similarly suppressed autologous CD4 (left), CD8 T- (middle), and NKT-cell (right) proliferation. In contrast, post-ASCT E- and M-MDSC phenotypes did not show suppressive effects on those immune cells. The data are presented as the mean ± SEM. **P < 0.01; ***P < 0.001

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