Skip to main content
Fig. 5 | Journal for ImmunoTherapy of Cancer

Fig. 5

From: Tbet-positive regulatory T cells accumulate in oropharyngeal cancers with ongoing tumor-specific type 1 T cell responses

Fig. 5

High frequencies of tumor-infiltrating Foxp3+ Tbet+ Tregs correlate with survival in OPSCC patients. Kaplan-Meier survival curves showing the outcome of 38 tested HPV16-positive OPSCC patients with high (above the median) and low (below the median) numbers of total CD8–Foxp3+, CD8–Foxp3+Tbet+ and CD8–Foxp3+Tbet– (top to bottom; left), and CD8–Foxp3–Tbet+, total T cell infiltrate (without CD8–Foxp3+Tbet+ cells) and total Tbet+ T cells/mm2 (top to bottom; right). T cell subsets were determined by IHC staining. Statistical significance of the survival distribution was analyzed by log-rank testing and differences were considered significant when p < 0.05, as indicated with an asterisk (*p < 0.05, **p < 0.01, *** p < 0.001 and **** p < 0.0001)

Back to article page