Prognostic value of CD8 + PD-1+ immune infiltrates and PDCD1 gene expression in triple negative breast cancer

Table 2 Multivariate analysis of CD8⁺PD-1⁺ double positive immune subsets with survival outcomes in patients with TNBC. Analysis was adjusted for tumor size, grade, age and lymph node status

Biomarkers	HR	95% CI	P-value
OS
CD8⁺PD-1⁺ immune infiltrates High vs. low	0.56	0.29–1.06	0.073
CD8⁺PD-1⁺ immune infiltrates High vs. low (adjusted for tumor size, grade, age and lymph node status and CD8⁺ total cell count)	0.77	0.35–1.67	0.510
DFS
CD8⁺PD-1⁺ immune infiltrates High vs. low	0.47	0.28–0.80	0.006*
CD8⁺PD-1⁺ immune infiltrates High vs. low (adjusted for tumor size, grade, age and lymph node status and CD8⁺ total cell count)	0.43	0.23–0.83	0.011*