Fig. 3

Immunization with MCMV-based vaccine vectors that induce substantial tumor-specific T cell responses via different routes of infection control tumor outgrowth. a TC-1 tumor outgrowth of unvaccinated mice and of mice previously vaccinated with MCMV-IE2-E7 via the IP, SC or IN route. The number of tumor-free/total mice is indicated in each graph. b The percentage of E7-specific CD8⁺ T cells within the total CD8⁺ T cell population in the blood (y-axis) plotted against the E7-specific CD8⁺ T cell response ranked from low to high (x-axis) of the mice that were either tumor-free (tumor-) or tumor positive (tumor+). c The mice that cleared the TC-1 tumor in A were re-challenged with 1 × 10⁵ C3 tumor cells. The number of tumor-free/total mice is indicated in each graph. Data are representative of two independent experiments with similar results