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Fig. 4 | Journal for ImmunoTherapy of Cancer

Fig. 4

From: Targeting the tumor stroma with an oncolytic adenovirus secreting a fibroblast activation protein-targeted bispecific T-cell engager

Fig. 4

Increased T cell accumulation in ICO15K-FBiTE tumors. NSG mice bearing A549 (lung carcinoma) tumors were intratumorally treated with PBS, ICO15K, or ICO15K-FBiTE (1 × 109 vp/tumor). Four days post-virus treatment, all mice received an intravenous injection of 1 × 107 LUC-T-cells (64% GFP+). Luciferase activity was analyzed by bioluminescence imaging (IVIS) daily until day 7. Mean values ± SEM with ≥5 animals per group are shown. ***, ICO15K-FBiTE significant (P < 0.001) by one-way ANOVA test with post hoc analysis compared to PBS and ICO15K groups

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