Table 2 Disease control for cell proliferation and PD-L1 IHC
From: Proliferative potential and resistance to immune checkpoint blockade in lung cancer patients
Cell Proliferation | PD-L1 IHC | DC | NDC | Total pts | DC rate | χ2 test |
|---|---|---|---|---|---|---|
Moderately | Â | 22 | 22 | 44 | 50.0% | Â |
Highly | 9 | 33 | 42 | 21.4% | p = 0.0146 | |
Poorly | 4 | 20 | 24 | 16.7% | p = 0.0113 | |
Poorly/highly | 13 | 53 | 66 | 19.7% | p = 0.0017 | |
|  | Strongly positive (TPS ≥ 50%) | 16 | 16 | 32 | 50.0% |  |
Not strongly positive (TPS < 50%) | 19 | 59 | 78 | 24.4% | p = 0.0009 | |
Positive (TPS ≥ 1%) | 21 | 32 | 53 | 39.6% |  | |
Negative (TPS < 1%) | 14 | 43 | 57 | 24.6% | p = 0.1363 | |
Moderate | Strongly positive (TPS ≥ 50%) | 10 | 7 | 17 | 58.8% |  |
Poorly/highly | 6 | 9 | 15 | 40.0% | p = 0.4786 | |
Moderately | Not strongly positive (TPS < 50%) | 12 | 15 | 27 | 44.4% |  |
Highly | 4 | 25 | 29 | 13.8% | p = 0.0250 | |
Poorly | 3 | 19 | 22 | 13.6% | p = 0.0438 | |
Poorly/highly | 7 | 44 | 51 | 13.7% | p = 0.0063 | |
Moderately cold tumors (CD8 rank < 15%) |  | 7 | 10 | 17 | 41.2% |  |
Poorly/highly cold tumors (CD8 rank < 15%) | 7 | 33 | 40 | 17.5% | p = 0.1179 | |
Moderately cold tumors (CD8 rank < 33%) |  | 5 | 5 | 10 | 50.0% |  |
Poorly/highly cold tumors (CD8 rank < 33%) | 0 | 11 | 11 | 0.0% | p = 0.3298 |