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Fig. 6 | Journal for ImmunoTherapy of Cancer

Fig. 6

From: Human double negative T cells target lung cancer via ligand-dependent mechanisms that can be enhanced by IL-15

Fig. 6

IL-15 enhances anti-tumor activity of DNTs in vitro and in vivo. a The cytotoxicity of DNTs against NSCLC cells in the presence or absence of IL-15 was determined by flow cytometry. This experiment was repeated using DNTs from 5 different donors with similar results. b A549 xenografts were treated with DNTs cultured with IL-2 or IL-2 plus IL-15, IL-2 and IL-15 were i.p. administered during the experiments. Mice were sacrificed on day 35 (n = 6/group). Two-tailed Student’s t test in a, two-way ANOVA followed by Bonferroni’s post hoc test in b. *P < 0.05, ***P < 0.001

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