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Table 2 Summary table of results from viral infectivity assay

From: A phase 1 dose escalation study of the oncolytic adenovirus enadenotucirev, administered intravenously to patients with epithelial solid tumors (EVOLVE)

Time point

Negative,a

n (%)

Positive,a n (%)

Total number of patient samples analyzed

 

Cells stain positive for virus

Plaques in monolayer

Complete/ partial monolayer destruction or quantifiable

Cycle 1, day 1 (day 0)

0 (0)

0

0

14 (100)

14

Cycle 2, day 1 (day 22)

3 (20)

0

4 (26.7)

8 (53.3)

15

Cycle 3, day 1 (day 43)

9 (75)

3 (25)

0

0

12

  1. aExample images for each level of infectivity are provided in Additional file 2: Figure S5