Fig. 1

Reduced number and function of infiltrating CD8⁺ T cells in tumor tissues of NSCLC than in the adjacent normal tissues. a, b The expression of CD8, Perforin, Granzyme B and IFN-γ was detected in samples from NSCLC patients (n = 100) using qRT-PCR. Data are given as means ± SEM. Significance is noted as **p < 0.0001. c, d Percentage of CD8, Perforin, Granzyme B and IFN-γ in samples from NSCLC patients via flow cytometry (n = 17), Data are given as means ± SEM. Significance is noted as *p < 0.05; **p < 0.0001. e, f, g, h Kaplan–Meier analysis of CD8, IFN-γ, Granzyme B and Perforin expression in NSCLC patients. n(total) = 100