Fig. 2

Inter-relationship of BMI, gender, serum creatinine and OS (a-i). Panel A shows the predominant male gender driven association of overweight/Class I obesity with lower risk of mortality (dark blue) compared to normal weight/underweight patients and Class II/III obese patients who had higher risk of mortality (red). Panel b shows that patients who had serum creatinine < 0.9 mg/dL had high risk of mortality and the obesity paradox pattern (blue) was largely attenuated. Panel c shows that the obesity paradox finding was attenuated for both genders if serum creatinine concentrations were < 0.9 mg/dL. Panel d shows that findings from Panel c were noted for both treatments (monotherapy/combination). Panel e shows an “L” shaped relationship of serum creatinine with OS. Panel f shows KM survival curves for the two creatinine risk groups per RSF thresholds (excluding 3 underweight patients). Panel g shows gender-based differences in distribution of serum creatinine within BMI groups where most females had serum creatinine < 0.9 mg/dL (risk threshold identified by RSF and is indicated as a red dashed line). Panel h shows that patients with serum creatinine ≥0.9 mg/dL who had longer survival were predominantly males than patients with serum creatinine < 0.9 mg/dL who were predominantly females. Panel i shows that overweight/Class I obese patients with serum creatinine > = 0.9 mg/dL had the longest OS