Fig. 3From: Complex inter-relationship of body mass index, gender and serum creatinine on survival: exploring the obesity paradox in melanoma patients treated with checkpoint inhibitionInter-relationship of BMI, gender, serum creatinine and PFS (a-f). Panel a shows the predominant male gender driven association of overweight/Class-I obesity with lower risk of progressive disease (dark blue) compared to normal weight/underweight patients and Class-III obese patients who had higher risk of disease progression (red). Panel b shows that patients who had serum creatinine < 0.9 mg/dL had high risk of progressive disease and the obesity paradox pattern (blue) was largely attenuated. Panel c shows that for both genders the paradox was attenuated if serum creatinine was < 0.9 mg/dL. Panel d shows that the findings from Panel c were noted both for anti-PD-1 based monotherapy and combination therapy. Panel e shows the relationship of serum creatinine with PFS and Panel f shows improved PFS for patients with serum creatinine > = 0.9 mg/dL compared to patients with levels < 0.9 mg/dLBack to article page